4-phenylpiperidine-4-carboxylic acid

4-phenylpiperidine-4-carboxylic acid - Names and Identifiers

Name	4-phenylpiperidine-4-carboxylic acid
Synonyms	BRN 0171176 Norpethidinic acid normeperidinicacid Normeperidinic acid 4-phenyl-isonipecoticaci n-demthylmeperidinicacid N-Demthylmeperidinic acid Isonipecotic acid, 4-phenyl- 4-phenyl-4-piperidinecarboxylicaci 4-phenylpiperidine-4-carboxylicacid 4-phenylpiperidine-4-carboxylic acid 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID 4-Piperidinecarboxylic acid, 4-phenyl- 5-22-02-00464 (Beilstein Handbook Reference) 4-Phenyl-4-piperidine carboxylic acid hydrochloride
CAS	3627-45-0
EINECS	222-844-0
InChI	InChI=1/C12H15NO2/c14-11(15)12(6-8-13-9-7-12)10-4-2-1-3-5-10/h1-5,13H,6-9H2,(H,14,15)

4-phenylpiperidine-4-carboxylic acid - Physico-chemical Properties

Molecular Formula	C12H15NO2
Molar Mass	205.25
Density	1.157g/cm³
Boling Point	374.9°C at 760 mmHg
Flash Point	180.5°C
Vapor Presure	2.75E-06mmHg at 25°C
Storage Condition	Room Temprature
Refractive Index	1.554

4-phenylpiperidine-4-carboxylic acid - Introduction

Acid, the chemical formula is C13H15NO2, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White solid
-Solubility: Soluble in organic solvents such as alcohols and ethers, insoluble in water
-melting point: about 160-165 degrees Celsius

Use:
-importantly acid can be used as a pharmaceutical intermediate and plays an important role in the synthesis of drugs.
-It is often used as a source for the preparation of β-imidic acids, piperidine esters and other compounds.

Preparation Method:
-the preparation of acid can be carried out by the following steps:
1. Reaction of benzyl bromopropane with benzaldehyde to give 4-phenyl -4-piperidinemethanol.
2.4-phenyl -4-piperidine methanol was oxidized to give 4-phenyl -4-piperidine aldehyde.
3. Finally, 4-phenyl -4-piperidine aldehyde is reacted with sodium cyanide to generate acid.

Safety Information:
-the acid is generally relatively safe under normal use, but it is still necessary to follow the relevant laboratory safety procedures.
-When handling and operating, you should wear protective gloves and glasses to avoid contact with skin, eyes or inhalation of dust.
-If inhaled or taken by mistake, seek medical attention immediately. If splashed into eyes or in contact with skin, flush with plenty of water and seek medical help.
-The safety data sheet of the substance should be read carefully before operation.

Last Update：2024-04-09 21:00:56